Adolescents and Young People aged 10 to 24 bear a disproportionate burden of HIV in Kenya. Those aged 15 to 24 are especially vulnerable, accounting for a third of all new HIV infections and 15% of all HIV-related deaths. Adolescents and young people living with HIV (AYPLHIV) tend to have lower suppression rates compared to adults, often due to lower treatment adherence and other factors such as lack of access to age-appropriate care, provider bias, and self-stigma. In response, Kenya’s National AIDS and STIs Control Programme launched Operation Triple Zero (OTZ). OTZ focuses on empowering both male and female AYPLHIV to commit to the “triple zero outcomes”: zero missed appointments, zero missed doses, and zero viral load. This brief outlines PATH’s OTZ activities and achievements-to-date under the PEPFAR and USAID-funded Afya Ziwani project in western Kenya.