Moving the Needle provides updates from PATH’s Center for Vaccine Innovation and Access (CVIA) on its vaccine development efforts, as well as related supporting work, such as developing human challenge models, building capacity of developing-country vaccine manufacturers, and evaluating new adjuvants and other novel vaccine technologies. It includes updates on our progress, partnerships, and specific activities. This is one of two newsletters published by CVIA. Immunization Matters covers CVIA’s vaccine uptake and access work.