RFP #2019-032 Preclinical Toxicokinetic Evaluation of Sublingual Oxytocin Tablets in Rabbits
Postpartum hemorrhage (PPH) is the most significant contributor to maternal mortality and morbidity worldwide. The World Health Organization recommends injectable oxytocin for treatment of PPH. As the recommended first-line medicine for prevention and treatment of PPH, oxytocin has limited use in resource-poor areas of the world mainly due to the lack of health workers with skills necessary for parenteral administration and the need for temperature-controlled storage to maintain the drug’s stability.
PATH has developed a heat-stable oxytocin fast-dissolving tablet presentation for sublingual needle-free administration and is seeking a nonclinical contract organization (CRO) to conduct a pilot non-good laboratory practice dose finding animal study in rabbits to assess the plasma levels of oxytocin obtained via the SL route of two formulations compared with the current intramuscular route of administration.
Confirmation of interest is due by November 26, 2019 with proposals due December 16, 2019.
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