The application of digital health technologies has the great potential to make a health system more responsive to health needs of the population. Thus, the Government of Tanzania, through the Ministry of Health, Community Development, Gender, Elderly and Children (MoHCDGEC), is committed to the effective application of digital technologies to improve population and individual health outcomes by facilitating evidence-based actions at all levels of the health system. The National Digital Health Strategy 2019–2024 outlines how Tanzania intends to leverage digital health technologies, build on the achievements, and experience from the implementation of the National eHealth Strategy 2013–2018. This strategy outlines what needs to be done from 2019 to 2024, to fast-track progress towards attainment of universal health coverage and the health-specific sustainable development goals. The strategy will also address challenges encountered in the digitalization of the health sector in Tanzania.