Since the COVID-19 pandemic, the Global Fund to Fight AIDS, Tuberculosis and Malaria (Global Fund) has become the largest source of external donor funding for medical oxygen, pulse oximetry, and respiratory therapies in low- and middle-income countries. Between 2021 and 2025, the Global Fund’s COVID-19 Response Mechanism invested around US$564 million to expand access to oxygen in over 80 low- and middle-income countries, financing more than 300 oxygen plants and training over 1,000 health professionals across almost 500 health facilities.

This brief, part of a series on Global health financing for oxygen systems, is intended to support applicants, partners, civil society, and others in developing funding requests and/or advocating for prioritization of medical oxygen, pulse oximetry, and respiratory therapies in grants from the Global Fund. It builds from previous efforts to support oxygen inclusion in Global Fund proposals.