Resources

Passive incidence of malaria cases is the main metric used in near-zero transmission settings in Senegal; other methods are needed to assess transmission interruption. These surveys aimed to assess malaria exposure in two regions of Senegal, describe historical changes in transmission, and identify the best sampling strategy for scale-up.

Since 2012, Senegal has implemented case investigation + reactive case detection (RCD) in the north: first with RCD + focal test and treat in the index household and neighbors, then focal screen test and treat, and eventually focal drug administration. This study examined the feasibility and efficacy of these methods.

Malaria indicator surveys have been implemented regularly in Zambia since 2006 to assess malaria prevalence. As Zambia targets elimination, tracking progress through the survey is increasingly difficult due to the sample size required. This study examines the ability of population genetics to assess transmission intensity in low-transmission settings.

This trial evaluated two malaria control approaches: reactive focal test and treat, and reactive focal drug administration. This is critical for Zambia, where malaria transmission is low enough in some areas that it is feasible to reactively seek and treat all infections in the index case and neighboring households.

Indoor residual spraying (IRS) and insecticide-treated bednets are pillars of Zambia’s strategy to eliminate malaria by 2021. This study reports on the impact of pirimiphos methyl IRS on malaria vector populations and transmission in parts of Southern Zambia targeted for malaria elimination.