Landscape analysis of potential technologies for manufacturing polio vaccines from non-infectious sources
The purpose of this project is to better understand the landscape of potential technologies for manufacturing polio vaccines from non-infectious sources, specifically S19, mRNA, and virus-like particle (VLP) platforms. Vaccines manufactured from non-infectious sources are an important tool in the post polio-eradication era given remaining risks of accidental poliovirus release into the environment. Results from the project provide in-depth information about the developability, acceptability and market demand for such next-generation polio vaccines. Articulating the relative pros and cons of each platform will help to guide future investment decisions. Key outputs analyzed include the following:
- The use case for future non-infectious polio vaccines
- Developability of the three potential non-infectious vaccine platforms
- The potential market and associated demand for a next-generation non-infectious polio vaccine
- Disease containment, including 1) guidelines for novel oral polio vaccines and S19, and 2) environmental and community impacts of accidental exposure under containment or temporary waived conditions (in progress)
Publication date: July 2025