Cholera remains a growing global public health threat, and the WHO-endorsed Controlled Temperature Chain (CTC) offers a practical way to improve access to oral cholera vaccines in high-risk, low-resource settings.

This guidance brief describes how CTC allows eligible oral cholera vaccines to be stored and transported outside the standard 2–8°C cold chain for defined periods, reducing logistical barriers and enabling faster, more equitable delivery.

Drawing on implementation experience from Bangladesh, Mozambique, and Zambia, the document outlines operational requirements, safety considerations, and key lessons learned, demonstrating that CTC can be safely applied to increase vaccination coverage, reduce costs, and support effective cholera outbreak prevention and response.