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  1. This spreadsheet provides publicly available information on clinical trials of Group B Streptococcus (GBS) candidate vaccines intended for disease prevention.Sources of information for these trials include clinicaltrials.gov, who.int/clinical-trials-registry-platform, clinicaltrialsregister.eu, chictr.org.cn, and anzctr.org.au.Some information is also obtained through contact with investigators, sponsors, and funders of vaccine clinical trials. This spreadsheet pairs with the GBS Vaccine Snapshot, which provides a summary of the GBS vaccine candidates in development worldwide.To share any updates or corrections to the tracker, please contact gbssnapshot@path.org.
    Published: July 2025
    Resource Page
    Part of a Series, Brief
  2. To support the development and introduction of more sensitive rapid diagnostic tests (RDTs) for malaria, PATH and the Institut Pasteur de Dakar partnered to evaluate the performance of three novel LDH-based RDTs developed by Rapigen (Republic of Korea). This study evaluated the clinical performance and usability of three of Rapigen’s BIOCREDIT RDTs among a febrile population in Kédougou, Senegal, comparing them to current tests (the standard HRP2-based RDT and microscopy) and against PCR and quantitative antigen reference assays. The following brief summarizes key results from this evaluation.
    Published: July 2025
    Resource Page
    Brief
  3. In 2017, African leaders made a historic commitment to improving access to lifesaving vaccines across the African continent by endorsing the Addis Declaration on Immunization (ADI). This pledge included a targeted goal to expand domestic investments, ensuring that every African benefits from immunization.The Africa Centers for Disease Control and Prevention (CDC) and the African Union Commission conducted a comprehensive review of the ADI to assess the implementation progress of the ten ADI commitments between 2017 and 2023, highlighting areas of slow advancement and disparities in progress among African Union member states. To corroborate this review, findings from a retrospective study, conducted by PATH’s Center for Advocacy and Policy, in nine African countries on immunization financing between 2017 and 2023, provided additional evidence—especially on the fluctuating trends in government financing for immunization.The following immunization advocacy resources include an overview Africa brief, and country-specific briefs that provide key findings and recommendations from the study and highlight common trends, challenges, and opportunities.
    Published: July 2025
    Resource Page
    Brief
  4. Chronic hepatitis B is commonly the result of vertical transmission, and babies who are infected before they are one year old have a 90% risk of developing chronic hepatitis. Yet when administered within 24 hours of birth, the hepatitis B birth dose vaccine can prevent 75% to 95% of vertical transmission.With funding from Gavi, the Vaccine Alliance, PATH is employing a mixed methods approach to assess learning questions on the feasibility, acceptability, cost, market access, and impact of innovative strategies to improve the reach of timely hepatitis B birth dose vaccine for babies born in both in- and out-of-facility settings.By exploring innovative delivery strategies, assessing the role of community health systems, and understanding stakeholder perspectives, the project’s primary objective is to identify effective models for increasing hepatitis B birth dose coverage. Evidence and insights from this initiative will be applicable to countries planning for hepatitis B birth dose vaccine introduction as well as those seeking to deploy new strategies to increase coverage rates and timely administration within 24 hours of birth.
    Published: July 2025
    Resource Page
    Brief, Fact Sheet
  5. To improve sustainability and strengthen the readiness of digital immunization systems for future pandemics, the Deutsche Gesellschaft für Internationale Zusammenarbeit (GIZ)’s Digital Innovation in Pandemic Control (DIPC) project works with ministries of health to select, adapt, and scale the use of robust digital tools.As an implementing partner of the DIPC project, Digital Square at PATH uses its expertise to create models for improved and more sustainable pandemic-prepared health systems with a focus on immunization workflows. Digital Square is working with three partner countries: Ghana, Malawi, and Tanzania. The following resources capture Digital Square’s support to Ghana within the DIPC project.
    Published: July 2025
    Resource Page
    Brief, Fact Sheet, Report