G6PD Operational Research Community of Practice
Advancing the use of G6PD tests at the point of care
The G6PD Operations Research Community of Practice (GORCoP) is a collaboration of researchers, organizations, malaria control programs, and clinicians committed to advancing the introduction and scale-up of glucose-6-phosphate dehydrogenase (G6PD) diagnostics in support of safe access to radical cure treatment for Plasmodium vivax malaria through operations research. There are several G6PD diagnostics available now and in the pipeline that have the potential to expand access to safe radical cure. The GORCoP seeks to understand and prepare for the transitions that health systems will need to undergo to adopt these tests.
This community of practice aims to harness best practices and lessons learned from multiple stakeholders, benefiting from the expertise of participants in areas such as diagnostic introduction, operations research, implementation science, quality assurance, and training. To support information sharing, the GORCoP maintains a digital central repository of resources that is accessible to all participants, hosts meetings and presentations, provides ongoing updates, and creates connections among participants.
The GORCoP maintains a digital repository of resources to support collaboration between national malaria control programs, researchers, and institutions working to advance the use of G6PD tests at the point of care. These resources include:
- Training materials.
- Quality assurance materials.
- Patient education materials.
- Sample protocols.
- Lessons learned from introducing G6PD tests.
Several public resources can be downloaded below. Join the community of practice for access to all resources.
Members of the community of practice are invited to join live webinars for presentations and discussions on the latest developments within G6PD operational research. These topics include lessons learned during training, research or implementations, and ethics and quality assurance for point-of-care testing.
Please join us for a 3-part webinar series on interpreting quantitative G6PD test results at the point of care.
Several factors contribute to the performance of G6PD tests at the point of care. This series will explore the influence of these factors on performance and will provide guidance on interpreting quantitative point-of-care test results for G6PD deficiency.
This webinar will explore the underlying epidemiology and case definitions used to evaluate point-of-care tests for G6PD deficiency. Learn about the implications of these factors on diagnostic performance.
Date: May 5, 7:00 am BST / 1 pm ICT
Speakers: Daniel Pfeffer, Menzies School of Health Research, Australia
Dr. Gonzalo Domingo, PATH, USA
An instrumented diagnostic test for G6PD deficiency that provides numerical results instead of a binary positive-negative result is a disruptive intervention in current malaria test and treat workflows. This webinar will look at the interpretation of the most available point-of-care G6PD test, the STANDARD™ G6PD Test, consider some of the factors discussed in the previous webinar, and seek to provide practical guidance on the interpretation of a quantitative G6PD test at the point of care.
Date: May 19, 7:00 am BST / 1 pm ICT
Speakers: Pooja Bansil and Emily Gerth-Guyette, PATH, USA
Menzies and FIND conducted a multi-laboratory assessment of the repeatability and reproducibility of the STANDARD G6PD Test. This webinar will present the outcomes of this assessment and compare these performance characteristics to that of the reference assay. The results of this study will help inform how to interpret the test at the point of care.
Date: June 2, 7:00 am BST / 1 pm ICT
Speaker: Dr. Benedikt Ley, APMEN Vivax Working Group, Menzies School of Health Research, Australia
January 19, 2021 webinar: Early experiences with point-of-care G6PD testing in malaria case management.
Scientists from UCSF, CMPE, PATH, and CHAI shared their early experiences and challenges of incorporating point-of-care testing for G6PD deficiency with Plasmodium vivax malaria case management in Laos, Cambodia, and Vietnam.
July 14, 2020 webinar: User perspectives on a quantitative G6PD test in Bangladesh. In this part two of the series on user perspectives from G6PD testing activities in Bangladesh, Nora Engel and Cristian Traian Ghergu from Maastricht University present a qualitative study that evaluated user perspectives on a quantitative G6PD test to support radical cure of P. vivax malaria in Bangladesh.
July 7, 2020 webinar: A training for health service providers on the SD Biosensor STANDARD G6PD test in Bangladesh. Mohammad Shafiul Alam, Associate Scientist at the Emerging Infections & Parasitology Laboratory of icddr,b, discussed the operations and findings from a training workshop for health service providers to support the implementation of the SD Biosensor STANDARD G6PD test in health facilities in Bangladesh.
April 7, 2020 webinar: Training healthcare providers for point of care G6PD testing in Brazil. Jose Diego de Brito Sousa, MSc, a Clinical Lab Scientist at the Amazonas State University in Brazil, discussed his experiences training healthcare providers to use the STANDARD G6PD test for the ongoing SAFEPRIM study in Manaus and Porto Velho. Diego also shared his experience working with both CareStart and STANDARD G6PD tests and his reasoning for preferring one test over the other.
October 30, 2019 webinar: Communicating Results and Counseling. Nicole van der Merwe, Ph.D., discussed foundational principles that genetic counselors use to ethically communicate individual findings. Eva Maria Cutiongco-De La Paz, MD, shared themes from the approach to counseling for G6PD as part of the Philippines National Institute of Health’s newborn screening program.
July 16, 2019 webinar: An Introduction to Quality Assurance in G6PD Testing. Germana Bancone, a research scientist with Shoklo Malaria Research Unit (SMRU), presented an introduction to quality assurance in G6PD testing. Maria Kahn, a senior research associate at PATH, discussed the importance of using control reagents in qualitative point-of-care assays for G6PD testing
April 10, 2019 webinar: G6PD Usability Testing and User Considerations. PATH shared results of usability testing from current quantitative G6PD tests and training materials that can be adapted for other operations research studies. Fundação de Medicina Tropical Doutor Heitor Vieira Dourado (FMT-HVD) presented training methods and materials from the SAFEPRIM study and Armed Forces Research Institute of Medical Sciences (AFRIMS) shared their diagnostic introduction activities in Cambodia.
For more information, please reach out to GORCoP@path.org.
This G6PD Operational Research Community of Practice is funded by grants from the Foreign, Commonwealth & Development Office (FDCO) and the Bill & Melinda Gates Foundation.