Shigellosis and enterotoxigenic Escherichia coli (ETEC)
Shigella and enterotoxigenic Escherichia coli (ETEC) are two of the leading bacterial causes of diarrhea worldwide, together killing more than one million people each year and hospitalizing millions more. Shigella and ETEC infections usually follow the ingestion of contaminated food or water and can be treated through rehydration therapy and antibiotics. Currently, no vaccines exist against Shigella or ETEC; however, vaccines against both diseases are under way.
More about shigellosis and ETEC | View resources on shigellosis and ETEC
Key resources
Development of a Low-Dose Challenge Model for Evaluation of Vaccines for Enterotoxigenic E. coli (ETEC) in Volunteers (2009)
A conference presentation that
provides results from a clinical trial that found the human challenge model currently being used to test vaccines against ETEC is utilizing a higher dose than is necessary to determine effectiveness.
Enteric Infections, Diarrhea, and Their Impact on Function and Development (2008)
A
review on the interactions between enteric pathogens and human genetic determinants that alter intestinal function and inflammation and profoundly impair human health and development.
Analysis of Strategies to Successfully Vaccinate Infants in Developing Countries Against Enterotoxigenic E. coli (ETEC) Disease (2008)
A review of vaccine candidates against ETEC and vaccine development issues, as well as considerations for a way forward.
Page last updated: November 2009.
