Publications

The American Academy of Microbiology has released its newest colloquium report, “Bringing the Lab to the Patient: Developing Point-of-Care Diagnostics for Resource Limited Settings.” We think this free report may be of interest to the members of Point-of-Care Diagnostics for Global Health.
The report is based on a colloquium convened in September 2011, where a diverse group of participants discussed three important questions:
• What diseases or medical conditions would benefit most from point-of-care diagnostics?
• What scientific and technological advances can be used to improve point-of-care diagnostics?
• What are the challenges to deploying point-of-care diagnostic tests?
The discussion of these pressing questions resulted in this informative report. One theme that is emphasized throughout the report is that communication among stakeholders is critical to the success of point-of-care diagnostic tests (POCTs). Only through communication is it possible to create effective POCTs and implement them where they are needed the most. Thus, by reading this report you are taking the first step in helping to create successful POCTs.
You may access the report in its entirety at:

The American Academy of Microbiology has released its newest colloquium report, “Bringing the Lab to the Patient: Developing Point-of-Care Diagnostics for Resource Limited Settings.” We think this free report may be of interest to the members of Point-of-Care Diagnostics for Global Health.
The report is based on a colloquium convened in September 2011, where a diverse group of participants discussed three important questions:

  • What diseases or medical conditions would benefit most from point-of-care diagnostics?
  • What scientific and technological advances can be used to improve point-of-care diagnostics?
  • What are the challenges to deploying point-of-care diagnostic tests?

The discussion of these pressing questions resulted in this informative report. One theme that is emphasized throughout the report is that communication among stakeholders is critical to the success of point-of-care diagnostic tests (POCTs). Only through communication is it possible to create effective POCTs and implement them where they are needed the most. Thus, by reading this report you are taking the first step in helping to create successful POCTs.
You may access the report in its entirety here.

Publications from PATH personnel

PATH publications

PATH publications, Diagnostics section

Selected publications by Center personnel and partners

  • Espinoza H, Sequeira M, Domingo G, Amador JJ, Quintanilla M, and de los Santos T. Management of the HIV epidemic in Nicaragua: the need to improve information systems and access to affordable diagnostics. Bulletin of the World Health Organization. 2011;89:619-620. Available at: http://www.who.int/bulletin/volumes/89/8/11-086124.pdf.
  • Boyle DB, Hawkins KR, Steele M, Singhal M, and Cheng X. Emerging Technologies for CD4 T-Lymphocyte Counting at the Point of Care. Trends in Biotechnology. 2011;Jul 26. PMID 21798607.
  • Domingo GJ, Hawkins KR, Peck RB, Weigl BH. Diagnostic Applications of Biomaterials. In: Biomaterials Science, 3rd Ed., Ratner, Hoffman, Schoen, and Lemons Third ed., ISBN0-1237-4626-4, Elsevier Academic Press, San Diego, CA, in press.
  • Waitumbi JN, Gerlach J, Afonina I, et al. Malaria prevalence defined by microscopy, antigen detection, DNA amplification, and total nucleic acid amplification in a malaria-endemic region during the peak malaria transmission season. Tropical Medicine and International Health. 2011;16(7):786-793.
  • Agarwal MM, Weigl BH, Hod M. Gestational diabetes screening: the low-cost algorithm, International Journal of Obstetrics and Gynecology, 2011, invited and submitted.
  • LaBarre P, Boyle D, Hawkins K, Weigl B. Instrument-free nucleic acid amplification assays for global health settings. Proceedings of SPIE 8029, 802902 (2011); doi:10.1117/12.882868.
  • Kubota R, LaBarre P, Singleton J, Beddoe A, Weigl BH, Alvarez AM, Jenkins DM. Non-Instrumented Nucleic Acid Amplification (NINA) for Rapid Detection of Ralstonia solanacearum Race 3 Biovar 2. In: Biological Engineering Transactions. 2011:4(2) ASABE ISSN 1934-2799, in press.
  • LaBarre P, Hawkins KR, Gerlach J, Wilmoth J, Beddoe A, Boyle D, Weigl B. A simple, inexpensive device for nucleic acid amplification without electricity—toward instrument-free molecular diagnostics in low-resource settings. PLoS ONE. 2011;6(5):e19738.
  • Barfield CA, Barney RS, Crudder CH, Wilmoth JL, Stevens DS, Mora-Garcia S, Yanovsky MJ, Weigl BH, Yanovsky J. A Highly Sensitive Rapid Diagnostic Test for Chagas Disease That Utilizes a Recombinant Trypanosoma cruzi Antigen. IEEE Transactions on Biomedical Engineering. 2011;58(3):814–817. PM:21342808.
  • Beyette FR, Jr., Gaydos CA, Kost GJ, Weigl BH. Point-of-Care Technologies for Health Care. IEEE Transactions on Biomedical Engineering. 2011;58(3):732–735. PM:21278008.
  • Curtis KA, Rudolph DL, Nejad I, Singleton J, Beddoe A, Weigl B, LaBarre P, Owen SM. Isothermal Amplification Using a Chemical Heating Device for Point-of-Care Detection of HIV-1, Journal of Virology. Submitted.
  • Niemz A, Ferguson T and Boyle DS. 2011. Point-of-care nucleic acid testing for infectious diseases. 2011. Trends in Biotechnology. May;29(5):240-250.
  • Puren A, Gerlach JL, Weigl BH, Kelso DM, Domingo GJ. Laboratory operations, specimen processing, and handling for viral load testing and surveillance. The Journal of Infectious Diseases. 2010;201 Suppl 1:S27–S36. PM:20225943.
  • Waitumbi J, Kuypers J, Anyona, Koros JN, Polhemus ME, Gerlach J, Steele M, Englund JA, Neuzil KM, Domingo GJ. Outpatient upper respiratory tract viral infections in children with malaria symptoms in western Kenya. American Journal of Tropical Medicine and Hygiene. 2010;83(5): 1010-1013.
  • Gerlach J, Sequeira M, Alvarado V, Cerpas C, Balmaseda A, Gonzalez A, de Los Santos T, Levin CE, Amador JJ, Domingo GJ. Cost analysis of centralized viral load testing for antiretroviral therapy monitoring in Nicaragua, a low-HIV prevalence, low-resource setting. Journal of the International AIDS Society. 2010;13:43.
  • LaBarre P, Gerlach J, Wilmoth J, Beddoe A, Singleton J, Weigl B. Non-instrumented nucleic acid amplification (NINA): instrument-free molecular malaria diagnostics for low-resource settings. Conference Proceedings of IEEE Engineering Medical Biological Society. 2010;2010:1097–1099.
  • Weigl BH, Boyle DS, de los Santos T, Peck RB, Steele MS. Simplicity of use: a critical feature for widespread adoption of diagnostic technologies in low-resource settings. Expert Review of Medical Devices. 2009;6(5):461–464. PM:19751117.
  • Kost GJ, Beyette FR, Gaydos C, Weigl BH. The NIBIB Point of Care Technologies Research Network Center themes and opportunities for exploratory POC projects. Point of Care: The Journal of Near-Patient Testing & Technology. 2008;7(1):41.
  • Gerdes JC, Weigl BH, Yager P, Tarr PI. Molecular (PCR-based) diagnostics for low-resource or point-of-care settings. Diagnostics for LDCs. 2008;1(5):22–25.
  • Weigl BH, Domingo G, LaBarre P, Gerlach J. Towards non- and minimally instrumented, microfluidics-based diagnostic devices. Lab on a Chip. 2008;8(12):1999–2014.
  • Weigl BH, de los Santos T, Steele M, Domingo GJ. High-tech IVDs for low-resource settings. IVD Technology Magazine. 2006;12(7):39–45.
  • Alary M, Gbenafa-Agossa C, Aina G, Ndour M, Labbe AC, Fortin D, Steele M, Peeling RW. Evaluation of a rapid point-of-care test for the detection of gonococcal infection among female sex workers in Benin. Sexually Transmitted Infections. 2006;82 Suppl 5:v29-v32. PM:17215275.

 

 

 

 

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