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Stability of Live Attenuated Rotavirus Vaccine With Selected Preservatives and Primary Containers

This article, published in Vaccine, reports the results of a study to evaluate the feasibility of using preservatives to develop a liquid multi-dose formulation and primary packaging alternatives for orally delivered, liquid rotavirus vaccines. The results showed that none of the preservatives tested were compatible with a live attenuated rotavirus vaccine, and the formulation without preservatives was stable in all primary containers tested. The study demonstrates that there are multiple options for the primary container for rotavirus vaccines intended for oral delivery, and selection of an optimal container should consider additional factors such as cold chain volume, usability, cost, and manufacturing feasibility. ABSTRACT ONLY. (Learn how users in developing countries can gain free access to journal articles.)

Author: Lal M, Jarrahian C, Zhu C, et al.

Published: 2016

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(Located at www.sciencedirect.com)

Citation: Lal M, Jarrahian C, Zhu C, et al. Stability of Live Attenuated Rotavirus Vaccine With Selected Preservatives and Primary Containers. Vaccine. 2016;34(22):2483-2489.

Resource types: Peer-reviewed journal

Diseases/vaccines: Rotavirus

Topics: Disease/vaccine specific information, Delivery technologies, Presentation and packaging, Vaccine stabilization and formulation

Regions: Global