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Systems Analysis of Protective Immune Responses to RTS,S Malaria Vaccination in Humans

RTS,S/AS01 is the most advanced malaria vaccine candidate in development, however very little is understood about how it induces immunity. This article, published in Proceedings of the National Academy of Sciences, uses a systems biology approach to analyze and compare two vaccination regimens of RTS,S: three consecutive vaccinations of RTS,S/AS01 versus a primary immunization with an adenovirus 35 vector expressing full-length circumsporozoite protein followed by two doses of RTS,S/AS01. The study found that protective immunity against the malaria parasite Plasmodium falciparum can be achieved through multiple pathways. The results also demonstrate the benefit of a systems biology approach to understanding how vaccination leads to protection from a disease. ABSTRACT ONLY. (Learn how users in developing countries can gain free access to journal articles.)

Author: Kazmin D, Nakaya HI, Lee EK, et al.

Published: 2017

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(Located at www.pnas.org)

Citation: Kazmin D, Nakaya HI, Lee EK, et al. Systems Analysis of Protective Immune Responses to RTS,S Malaria Vaccination in Humans. Proceedings of the National Academy of Sciences. 2017;114(9):2425-2430

Resource types: Peer-reviewed journal

Diseases/vaccines: Malaria

Topics: Vaccine safety and performance, Disease/vaccine specific information

Regions: Global