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Efficacy and Safety of RTS,S/AS01 Malaria Vaccine With or Without a Booster Dose in Infants and Children in Africa: Final Results of a Phase 3, Individually Randomized, Controlled Trial

This article, published in The Lancet, reports the results of a study on the efficacy and safety of the RTS,S/AS01 candidate malaria vaccine. The authors conclude that RTS,S/AS01 prevented a substantial number of cases of clinical malaria over a three to four year period in young infants and children with or without a booster dose, and efficacy was enhanced by the administration of a booster dose. They note that the vaccine has the potential to make a substantial contribution to malaria control when used in combination with other effective control measures.

Author: RTS,S Clinical Trials Partnership

Published: 2015

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(Located at www.thelancet.com)

Citation: RTS,S Clinical Trials Partnership. Efficacy and Safety of RTS,S/AS01 Malaria Vaccine With or Without a Booster Dose in Infants and Children in Africa: Final Results of a Phase 3, Individually Randomized, Controlled Trial. The Lancet. 2015;386(9988):31-45.

Resource types: Peer-reviewed journal

Diseases/vaccines: Malaria

Topics: Vaccine safety and performance, Disease/vaccine specific information

Regions: Africa