More than 150 leading global health and development thinkers convened on June 15, 2016, for The Innovation Effect: Powering Disruptive Global Health Solutions in Washington, DC. This conference report provides an overview of the insights shared when attendees explored what happens when unique partnerships, disruptive technologies, transformed systems, and data-driven insights combine in often unexpected ways to create dramatic improvements in the health and well-being of people around the world.