One potential way to improve coverage of basic vaccines is to combine several vaccine antigens into one injection that is delivered with an easy-to-use, single-dose, autodisable device. Pentavalent vaccine in the prefilled Uniject™ injection system provides this format. To assess the readiness of stakeholders to accept this product presentation, we conducted interviews and discussion groups with health care workers, policy and procurement officers, and Expanded Programme on Immunization (EPI) managers in six countries.