HIV/AIDS and its cross-border transmission in the Mekong region is a growing problem. In response to this problem, PATH, supported by the United States Department of State, implemented the project entitled "Catalyzing Cross-Border HIV/AIDS Prevention in the Southern China Border Region." The project aimed to attract the attention of different stakeholders on both sides of the border to develop The Action Plan to deal with this epidemic. There was a lack of clear understanding of local situations to develop a comprehensive action plan that was locally and culturally appropriate, feasible, and effective. Three cross-border sites, therefore, were selected to conduct the needs assessment: Vietnam, China, and Myanmar. This report presents the findings from Lao Cai and Lang Son provinces in Vietnam.