Vaccine stabilization

Thermostable vaccines can improve the effectiveness and efficiency of immunizations by preventing temperature damage to vaccines (caused by exposure to high heat or freezing), reducing vaccine wastage, and decreasing logistical and equipment requirements as well as the costs of vaccine transportation and storage—especially at the periphery of the cold chain. Thermostable vaccines also have the potential to facilitate coverage gains by enabling vaccine delivery in remote areas beyond the reach of the existing cold chain. Additional benefits, such as improved vaccine safety and superior product formats, are possible depending on the stabilization methods used.

For more than a decade, PATH has conducted research on both the technical and commercial feasibility of improving the thermostability of vaccines. It has identified and evaluated novel vaccine formulations and processing technologies as well as investigated the economic, logistical, regulatory, procurement, and policy issues associated with development, licensing, and use of stabilized vaccines. Visit PATH’s website to learn more about its ongoing work to optimize vaccine stability, conducted in collaboration with vaccine producers, vaccine development projects, technology companies, laboratories, and universities, among others.

View resources on vaccine stabilization

Key resources

Vaccines With Aluminum-Containing Adjuvants: Optimizing Vaccine Efficacy and Thermal Stability (2010)
An article that discusses optimizing the stability of aluminum-adjuvanted vaccines.

Stability of Vaccines – Bridging From Stability Data to Continuous Safety and Efficacy Throughout Shelf Life – An Always Reliable Approach? (2009)
An article on why stability studies are important tools to reliably ensure the long-term efficacy and safety of vaccines.

Featured PATH resources

Vaccine Stabilization (2012)
A fact sheet that describes PATH's work on vaccine stabilization.

Summary of Vaccine Stability Data (2012)
Two documents that provide the latest stability data for commonly used vaccines and current research on vaccine formulations and platform technologies.

Page last updated: October 2013.