Vaccine stabilization and formulation

Thermostable vaccines can improve the effectiveness and efficiency of immunizations by preventing temperature damage (that can result from vaccine exposure to high heat or freezing), reducing vaccine wastage, easing logistical and equipment requirements, and decreasing transportation and storage costs, especially at the periphery of the cold chain. Thermostable vaccines also have the potential to facilitate coverage gains by enabling vaccine delivery in remote areas beyond the reach of the cold chain. Additional benefits, such as improved vaccine safety and superior product formats, are possible depending on the formulation and stabilization methods used.

For more than a decade, PATH has conducted research on both the technical and commercial feasibility of improving the thermostability of vaccines. It has identified and evaluated novel vaccine formulations and processing technologies as well as investigated the economic, logistical, regulatory, procurement, and policy issues associated with development, licensing, and use of stabilized vaccines. Visit PATH’s website to learn more about its various accomplishments and ongoing work to optimize vaccine stability, in collaboration with vaccine producers, vaccine development projects, technology companies, laboratories, and universities, among others.

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Page last updated: November 2015.

Photo: Umit Kartoglu.