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Investigation of Different Group A Immunoassays Following One Dose of Meningococcal Group A Conjugate Vaccine or A/C Polysaccharide Vaccine in Adults

This article, published in Clinical and Vaccine Immunology, details further analysis of the sera from a previous Phase 1 study to assess the safety, immunogenicity, and antibody persistence of a new group A conjugate vaccine, using four additional immunologic assays to investigate the relationship between the different immunoassays. The immunoassays employed were an SBA assay that used human complement, a group A-specific IgG multiplexed bead assay, and two opsonophagocytic antibody assays, which used two different methodologies. The study found that, other than the two antibody binding assays (ELISA and multiplex bead assay), none of the serogroup A immunoassays showed sufficiently high correlation to consider one assay able to predict or represent another assay. This study may be useful in examining postimmunization efficacy data in relation to serogroup A immunoassays.

Author: Findlow H, Plikaytis BD, Aase A, et al.

Published: 2009

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(Located at cvi.asm.org)

Citation: Findlow H, Plikaytis BD, Aase A, et al. Investigation of Different Group A Immunoassays Following One Dose of Meningococcal Group A Conjugate Vaccine or A/C Polysaccharide Vaccine in Adults. Clinical and Vaccine Immunology. 2009;16(7):969-977.

Resource types: Peer-reviewed journal

Diseases/vaccines: Meningococcus

Topics: Disease/vaccine specific information

Regions: Asia