Dynamic Models of Meningococcal Carriage, Disease, and the Impact of Serogroup C Conjugate Vaccination

The authors of this article, published in The American Journal of Epidemiology, use data on immunization with serogroup C meningococcal conjugate vaccines in England and Wales to develop and apply a mathematical model that investigates the direct and indirect (herd immunity) effects of a conjugate vaccine program. Analysis of different vaccine strategies under the model suggests that a routine infant vaccination program without a catch-up component is the least effective vaccination strategy because children are protected for only a short period of time and herd effects are minimal.

Author(s): Trotter CL, Gay NJ, Edmunds WJ

Published: 2005

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    Citation: Trotter CL, Gay NJ, Edmunds WJ. Dynamic Models of Meningococcal Carriage, Disease, and the Impact of Serogroup C Conjugate Vaccination. American Journal of Epidemiology. 2005;162(1):89-100.