Prevention of Secondary Cases of Meningococcal Disease in Household Contacts by Vaccination

This article, published in The British Medical Journal, describes a study of secondary meningococcal disease infection in which researchers used either meningococcal or tetanus toxoid vaccine to immunize household contacts of patients with group A meningococcal infection in Nigeria. Only one possible case of meningococcal infection occurred among 520 contacts vaccinated with meningococcal vaccine. The study concluded that vaccine alone seemed to provide adequate prophylaxis in the subjects studied, but that additional chemoprophylaxis could be necessary to cover the critical days following the primary infection.

Author(s): Greenwood BM, Hassan-King M, Whittle HC

Published: 1978

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    Citation: Greenwood BM, Hassan-King M, Whittle HC. Prevention of Secondary Cases of Meningococcal Disease in Household Contacts by Vaccination. British Medical Journal. 1978;1(6123):1317-1319.