Expanding Prevention of Invasive Meningococcal Disease

This article, published in Expert Review of Vaccines, discusses morbidity and mortality due to meningococcal serogroups A, C, Y, and W-135 and the ability of monovalent meningococcal serogroup C conjugate (MCC) vaccines to reduce the burden of disease. Evidence from MCC and other conjugate vaccine initiatives supports immunization initiated as a late-infancy/toddler program for prevention of disease caused by serogroups C, Y, and W-135. Based on the review, the authors propose that a meningococcal vaccination program focused on later infancy and the early second year of life should be the preferred approach, providing comparable effectiveness to an early-infant strategy with fewer overall doses and greater cost-effectiveness. ABSTRACT ONLY. (Learn how users in developing countries can gain free access to journal articles.)

Author(s): Pelton SI, Gilmet GP

Published: 2009

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    (Located at www.ncbi.nlm.nih.gov)

    Citation: Pelton SI, Gilmet GP. Expanding Prevention of Invasive Meningococcal Disease. Expert Review of Vaccines. 2009; 8(6):717-727.