This article, published in Infection and Immunity, reviews the serological basis for use of meningococcal serogroup C conjugate vaccines in the United Kingdom and applies the criteria to toddlers to evaluate immune response. The results indicate that the majority of toddlers with a serum bactericidal assay using rabbit complement titer between 8 and 64, and some of those with a serum bactericidal assay using human complement result of less than 4, have mounted a protective immune response with the induction of immunological memory.

Author(s): Borrow R, Andrews N, Goldblatt D, Miller E

Published: 2001

Resource types: Peer-reviewed journal

Diseases: Meningococcus

Topics: Disease/vaccine specific information

Regions: North America and Europe