Development of a Low-Dose Challenge Model for Evaluation of Vaccines for Enterotoxigenic E. coli (ETEC) in Volunteers

This presentation from the Vaccines for Enteric Diseases conference provides results from a clinical trial that found the human challenge model currently being used to test vaccines against enterotoxigenic Escherichia coli (ETEC) is utilizing a higher dose than is necessary to determine effectiveness, which may result in premature elimination of promising vaccines that could work in developing-country populations. The study determined that the ETEC H10407 challenge model, administered at the 107 dose with an overnight fast, induces a reproducible attack rate of at least 70 percent and similar disease severity as higher dose models.

Author(s): Harro C, DeNearing B, Marcum A, et al.

Published: 2009

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    Citation: Harro C, DeNearing B, Marcum A, et al. Development of a Low-Dose Challenge Model for Evaluation of Vaccines for Enterotoxigenic E. coli (ETEC) in Volunteers. Presented at: Vaccines for Enteric Diseases, September 2009; Malaga, Spain.