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Clonal Waves of Neisseria Colonisation and Disease in the African Meningitis Belt: Eight-Year Longitudinal Study in Northern Ghana

This study, published in PLoS Medicine, aimed to determine how levels of colonization with different bacterial meingococcal serogroups change over time, and how the patterns of disease relate to such changes in the Kassena-Nankana District of northern Ghana. The study observed that lack of a temporally stable and genetically diverse resident pharyngeal flora of meningococci might contribute to the susceptibility to meningococcal disease epidemics of residents in the African Meningitis Belt.

Author: Leimkugel J, Hodgson A, Forgor AA, et al.

Published: 2007

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(Located at www.pubmedcentral.nih.gov)

Citation: Leimkugel J, Hodgson A, Forgor AA, et al. Clonal Waves of Neisseria Colonisation and Disease in the African Meningitis Belt: Eight-Year Longitudinal Study in Northern Ghana. PLoS Medicine. 2007;4(3):e101.

Resource types: Peer-reviewed journal

Diseases/vaccines: Meningococcus

Topics: Disease burden and surveillance, Disease/vaccine specific information

Regions: Africa