Cross-Reactive Antibody Responses to the 2009 Pandemic H1N1 Influenza Virus
This article, published in The New England Journal of Medicine, describes a study to assess preexisting immunity in humans to the new pandemic influenza A(H1N1) virus in order to evaluate seasonal vaccine strategies. Researchers used a microneutralization assay to measure cross-reactive antibodies to the 2009 pandemic influenza A(H1N1) virus in serum samples from persons either vaccinated with recent seasonal or 1976 swine influenza vaccines. The authors conclude that seasonal vaccination does not induce a cross-reactive antibody response against the 2009 influenza A(H1N1) virus in any age group. Likewise, they found little evidence to support the presence of cross-reactive antibodies in persons under 30 years of age. They did find, however, that some older adults exhibited preexisting cross-reactive antibodies.
Author(s): Hancock K, Veguilla V, Lu X, et al.
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Citation: Hancock K, Veguilla V, Lu X, et al. Cross-Reactive Antibody Responses to the 2009 Pandemic H1N1 Influenza Virus. New England Journal of Medicine. 2009. Epub ahead of print.