Artemisinin Resistance in Plasmodium falciparum Malaria
This study, published in the New England Journal of Medicine, compares the efficacies of two treatments--oral artesunate and artesunate followed by mefloquine--for uncomplicated falciparum malaria in Pailin, western Cambodia, and Wang Pha, northwestern Thailand, historically sites of emerging antimalarial-drug resistance. The study concludes that P. falciparum has reduced in vivo susceptibility to artesunate in western Cambodia, as compared with northwestern Thailand, and that containment measures are urgently needed.
Author(s): Dondorp AM, Nosten F, Yi P, et al.
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Citation: Dondorp AM, Nosten F, Yi P, at al. Artemisinin Resistance in Plasmodium falciparum Malaria. New England Journal of Medicine. 2009;361(5):455-467.