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Safety and Immunogenicity of Concomitant Vaccination With the Cell-Culture Based Japanese Encephalitis Vaccine IC51 and the Hepatitis A Vaccine HAVRIX1440 in Healthy Subjects: A Single-Blind, Randomized, Controlled Phase 3 Study

In travelers often several pre-departure immunizations are indicated, thus data are needed about possible interactions between vaccines. This Phase 3 study investigated the immunogenicity and safety of IC51 (JE vaccine) and HAVRIX1440 (hepatitis A vaccine) when administered alone or concomitantly to healthy subjects. Immunogenicity was comparable for the two vaccines whether given together or separately, which suggests that travelers to such regions could receive the vaccinations concomitantly.

Author: Kaltenböck A, Dubischar-Kastner K, Eder G, et al.

Published: 2009

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Kaltenböck A, Dubischar-Kastner K, Eder G, et al. Safety and immunogenicity of concomitant vaccination with the cell-culture based Japanese Encephalitis vaccine IC51 and the hepatitis A vaccine HAVRIX1440 in healthy subjects: A single-blind, randomized, controlled Phase 3 study. Vaccine. 2009;27(33):4483-4489.

Resource types: Peer-reviewed journal

Diseases/vaccines: Japanese encephalitis

Topics: Vaccine safety and performance, Disease/vaccine specific information

Regions: Global