Rotavirus Vaccines--Early Success, Remaining Questions
In this editorial, published in the New England Journal of Medicine, the authors discuss the introduction of two new rotavirus vaccines, RotaTeq and Rotarix, in the United States. Vaccine use showed marked change in rotavirus activity for 2008, even with modest coverage, and data also suggest that vaccination may be causing indirect benefits among unvaccinated children. Evidence of the vaccines' performance in the developing world is still needed, and eagerly awaited data from clinical trials in Asia and Africa will inform WHO's consideration of a universal recommendation and GAVI support for rotavirus vaccines in these regions.
Author: Parashar UD, Glass RI
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Citation: Parashar UD, Glass RI. Rotavirus Vaccines--Early Success, Remaining Questions. New England Journal of Medicine. 2009;360(11):1063-1065.
Resource types: Peer-reviewed journal