PATH | VRL
Menu

Efficacy of a Pneumococcal Conjugate Vaccine Against Acute Otitis Media

This study, published in the New England Journal of Medicine, enrolled 1662 infants in a randomized, double-blind efficacy trial of a heptavalent pneumococcal polysaccharide conjugate vaccine in which the carrier protein is the nontoxic diphtheria-toxin analogue CRM197. The children received either the study vaccine or a hepatitis B vaccine as a control at 2, 4, 6, and 12 months of age. The clinical diagnosis of acute otitis media was based on predefined criteria, and the bacteriologic diagnosis was based on a culture of middle-ear fluid obtained by myringotomy.

Author: Eskola J, Kilpi T, Palmu A, et al.

Published: 2001

» Visit web page (English)

(Located at content.nejm.org)

Citation: Eskola J, Kilpi T, Palmu A, et al. Efficacy of a Pneumococcal Conjugate Vaccine Against Acute Otitis Media. New England Journal of Medicine. 2001;344(6):403-409.

Resource types: Peer-reviewed journal

Diseases/vaccines: Pneumococcus

Topics: Disease/vaccine specific information

Regions: Global