Immunization with the Heptavalent Pneumococcal Conjugate Vaccine in Bangladeshi Infants and Effects of Zinc Supplementation
Published in the journal Vaccine, this article aimed to determine the immunogenicity of the heptavalent pneumococcal protein conjugate (PNC) vaccine in poor Bangladeshi infants and to assess the effect of zinc supplementation on immune response to the PNC vaccine. The study immunized a sub-cohort of 241 infants who had previously received three doses of a Hib conjugate vaccine with three doses of the heptavalent PNC vaccine at 4 weeks intervals beginning at 18 ± 1 weeks of age. The infants were supplemented with daily 5 mg zinc or placebo from 4 to 33 weeks of age. Response to each of the seven PNC serotypes were assessed at 4, 24 and 33 weeks of age.
Author(s): Osendarp SJM, Prabhakar H, Fuchs GJ, et al.
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Citation: Osendarp SJM, Prabhakar H, Fuchs GJ, et al. Immunization with the Heptavalent Pneumococcal Conjugate Vaccine in Bangladeshi Infants and Effects of Zinc Supplementation. Vaccine. 2007;25(17):3347-3354.