Vaccines in the Era of Genomics: The Pneumococcal Challenge
Published in the journal Vaccine, this review aims to provide the reader with an understanding of the capsular-based complexity of Streptococcus pneumoniae, one of the main limitations to current vaccine development; the need for a new vaccine strategy based on proteic antigen candidates discovered in silico; and the importance of defining the pan-genome of the pneumococcus, that is, the sequencing and analysis of multiple genomes from the same species.
Author(s): Barocchi MA, Censini S, Rappuoli R
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Citation: Barocchi MA, Censini S, Rappuoli R. Vaccines in the Era of Genomics: The Pneumococcal Challenge. Vaccine. 2007;25(16):2963-2973.