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Two-Dose Schedules for Human Papillomavirus Vaccine: Systematic Review and Meta-Analysis

This article, published in Vaccine, reports the results of a study comparing the effects of a two-dose versus a three-dose immunization schedule for human papillomavirus (HPV) vaccine. According to the evidence systematically reviewed in this study, a two-dose HPV vaccine schedule in adolescent girls produces noninferior antibody responses compared to the standard three-dose schedule. Currently, global adoption of the two-dose schedule is limited, particularly in countries with the highest burden of cervical cancer.

Author: D'Addario M, Redmond S, Scott P, et al.

Published: 2017

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(Located at www.sciencedirect.com)

Citation: D'Addario M, Redmond S, Scott P, et al. Two-Dose Schedules for Human Papillomavirus Vaccine: Systematic Review and Meta-Analysis. Vaccine. 2017;35(22):2892-2901.

Resource types: Peer-reviewed journal

Diseases/vaccines: Human papillomavirus (HPV)

Topics: Vaccine safety and performance, Disease/vaccine specific information

Regions: Global