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Needle-Free Jet Injector Intradermal Delivery of Fractional Dose Inactivated Poliovirus Vaccine: Association Between Injection Quality and Immunogenicity

The polio end-game strategy recommends the introduction of inactivated poliovirus vaccine (IPV) in all countries currently using only oral poliovirus vaccine. Administration of fractional dose IPV (fIPV) by intradermal injection may reduce the costs associated with IPV introduction. This article, published in Vaccine, examines the feasibility of fIPV delivery using needle-free injector devices compared to conventional fIPV injection with a needle and syringe. The results indicate that fIPV delivery using needle-free injector devices is feasible, with high acceptability among health workers. Injection quality indicators were not observed to be uniformly associated with immune response. ABSTRACT ONLY. (Learn how users in developing countries can gain free access to journal articles.)

Author: Resik S, Tejeda A, Mach O, et al.

Published: 2015

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Citation: Resik S, Tejeda A, Mach O, et al. Needle-Free Jet Injector Intradermal Delivery of Fractional Dose Inactivated Poliovirus Vaccine: Association Between Injection Quality and Immunogenicity. Vaccine. 2015;33(43):5873-5877.

Resource types: Peer-reviewed journal

Diseases/vaccines: Polio

Topics: Disease/vaccine specific information, Delivery technologies

Regions: Latin America and the Caribbean