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Predicting RTS,S Vaccine-Mediated Protection From Transcriptomes in a Malaria-Challenge Clinical Trial

While the RTS,S malaria vaccine can protect against controlled human malaria infection (CHMI), little is known about how it induces an immune response. This article, published in Frontiers in Immunology, reports the results of a study that examined the immunogenicity and peripheral blood transcriptome data from a clinical trial in which healthy adults received three doses of RTS,S four weeks apart, followed by a CHMI using Plasmodium falciparum. The study conducted a systems biology analysis, which determined that RTS,S-induced memory responses were capable of mobilizing natural killer cells or other sources of IFN-γ production in the protective response. It also identified genes that could be useful in understanding how RTS,S induces protection against malaria parasitemia and that warrant further study.

Author: van den Berg RA, Coccia M, Ballou WR, et al.

Published: 2017

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(Located at journal.frontiersin.org)

Citation: van den Berg RA, Coccia M, Ballou WR, et al. Predicting RTS,S Vaccine-Mediated Protection From Transcriptomes in a Malaria-Challenge Clinical Trial. Frontiers in Immunology. 2017; 8(557).

Resource types: Peer-reviewed journal

Diseases/vaccines: Malaria

Topics: Vaccine safety and performance, Disease/vaccine specific information

Regions: Global