Vaccine Vial Stopper Performance for Fractional Dose Delivery of Vaccines
This article, published in Human Vaccines & Immunotherapeutics, examines the performance of three types of vaccine vial stopper used in World Health Organization (WHO)-prequalified inactivated poliovirus vaccine (IPV) and yellow fever vaccine (YFV). To alleviate global shortages and expand population coverage, the WHO recommends administering fractional doses of both vaccines, which requires an increase in the number of vial stopper punctures when drawing from existing 5- and 10-dose vaccine vials. The authors assessed the stoppers and found that all stoppers tested maintained self-sealing capacity after 100 punctures and resisted fragmentation damage up to at least 50 punctures. These results support the use of existing IPV and YFV vials for fractional dose delivery.
Author: Jarrahian C, Myers D, Creelman B, Saxon E, Zehrung D
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Citation: Jarrahian C, Myers D, Creelman B, Saxon E, Zehrung D. Vaccine Vial Stopper Performance for Fractional Dose Delivery of Vaccines. Human Vaccines & Immunotherapeutics. 2017;13(7):1666-1668.
Resource types: Peer-reviewed journal