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Cost-Effectiveness Analysis of Typhoid Conjugate Vaccines in Five Endemic Low- and Middle-Income Settings

Typhoid fever remains endemic in low- and middle-income countries, yet programmatic use of existing vaccines is limited. This article, published in Vaccine, evaluates the cost-effectiveness of five typhoid conjugate vaccine (TCV) delivery strategies in urban and rural settings in India, Kenya, and Vietnam using a dynamic model of typhoid transmission to simulate cases, hospitalizations, deaths, disability-adjusted life-years lost, treatment, and intervention costs. The model predicted significant decreases in typhoid incidence from any of the delivery strategies examined. The authors found that routine vaccination with TCV would be cost-effective in most settings, and additional one-time catch-up campaigns would also be economically justified.

Author: Antillón M, Bilcke J, Paltiel AD, Pitzer VE

Published: 2017

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Citation: Antillón M, Bilcke J, Paltiel AD, Pitzer VE. Cost-Effectiveness Analysis of Typhoid Conjugate Vaccines in Five Endemic Low- and Middle-Income Settings. Vaccine. 2017;35(27):3506-3514.

Resource types: Peer-reviewed journal

Diseases/vaccines: Typhoid

Topics: Introduction and service delivery, Immunization financing, Disease/vaccine specific information

Regions: Africa, Asia