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Burden of Typhoid Fever in Low-Income and Middle-Income Countries: A Systematic, Literature-Based Update With Risk-Factor Adjustment

This article, published in The Lancet Global Health, reports the results of a study that aimed to estimate the burden of typhoid in low- and middle-income countries. The authors found that after adjusting for water-related risk, there was an estimated 11.9 million cases with 129,000 deaths in 2010, whereas the unadjusted burden was 20.6 million cases and 223,000 deaths. The authors note that the risk-adjusted typhoid burden estimate was more conservative than previous estimates, and distinguishing the risk differences will facilitate cost-effectiveness calculations for risk-based vaccination strategies.

Author: Mogasale V, Maskery B, Ochiai RL, et al.

Published: 2014

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(Located at www.thelancet.com)

Citation: Mogasale V, Maskery B, Ochiai RL, et al. Burden of Typhoid Fever in Low-Income and Middle-Income Countries: A Systematic, Literature-Based Update With Risk-Factor Adjustment. The Lancet Global Health. 2014;2(10):e570-e580.

Resource types: Peer-reviewed journal

Diseases/vaccines: Typhoid

Topics: Disease burden and surveillance, Disease/vaccine specific information

Regions: Global