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Persistence of Functional Antibodies to Group B Streptococcal Capsular Polysaccharides Following Immunization With Glycoconjugate Vaccines

This article, published in Vaccine, evaluates the duration of functional activity of group B streptococcal (GBS) glycoconjugate vaccine-induced capsular polysaccharide (CPS)-specific IgG among healthy adults. The study reveals that opsonophagocytic activity declined significantly from a 4-week post-immunization peak, but substantial functional activity was retained at 18 months to 2 years post-immunization for each GBS type assessed. The authors argue that persistence of functional antibody activity, even when GBS CPS-specific IgG concentrations decline, suggests that long-term protection may be expected from candidate GBS glycoconjugate vaccines. ABSTRACT ONLY. (Learn how users in developing countries can gain free access to journal articles.)

Author: Edwards MS, Lane HJ, Hillier SL, Rench MA, Baker CJ

Published: 2012

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(Located at www.sciencedirect.com)

Citation: Edwards MS, Lane HJ, Hillier SL, Rench MA, Baker CJ. Persistence of Functional Antibodies to Group B Streptococcal Capsular Polysaccharides Following Immunization With Glycoconjugate Vaccines. Vaccine. 2012;30(28):4123-4126.

Resource types: Peer-reviewed journal

Diseases/vaccines: Group B Streptococcus (GBS)

Topics: Vaccine safety and performance, Disease/vaccine specific information

Regions: North America and Europe