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Antibody-Independent Classical Pathway-Mediated Opsonophagocytosis of Type Ia, Group B Streptococcus

This article, published in The Journal of Clinical Investigation, elborates on experiements that indicate substances other than the exposed surface of the type Ia capsular polysaccharide initiate classical pathway-mediated opsonophagocytosis of clinical isolates of type Ia, group B streptococci by human sera in the absence of immunoglobulin. The authors suggest that a deficiency in classical complement pathway function may be critical to the susceptibility of neonates to type Ia, group B streptococcal disease.

Author: Baker CJ, Edwards MS, Webb BJ, Kasper DL

Published: 1982

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(Located at www.jci.org)

Citation: Baker CJ, Edwards MS, Webb BJ, Kasper DL. Antibody-Independent Classical Pathway-Mediated Ppsonophagocystosis of Type Ia, Group B StreptococcusThe Journal of Clinical Investigation. 1982;69(2):394-404. 

Resource types: Peer-reviewed journal

Diseases/vaccines: Group B Streptococcus (GBS)

Topics: Disease/vaccine specific information

Regions: North America and Europe