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Preventing Bacterial Infections With Pilus-Based Vaccines: The Group B Streptococcus Paradigm

This article, published in the Journal of Infectious Diseases, reports the results of a study that determined whether a vaccine containing a combination of proteins from three pilus types can provide broad protection against group B Streptococcus (GBS) by analyzing pili distribution and conservation in 289 clinical isolates. The article notes that pilus sequences in each island are conserved, all strains carry at least one of the three islands, and a combination of the three pilus components conferred protection against all tested GBS challenge strains in mice. The authors suggest these data are the first to indicate that a vaccine exclusively consitituted by pilus components can be effective in preventing infections caused by GBS.

Author: Margarit I, Rinaudo CD, Galeotti CL, et al.

Published: 2009

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(Located at academic.oup.com)

Citation: Margarit I, Rinaudo CD, Galeotti CL, et al. Preventing Bacterial Infections With Pilus-Based Vaccines: The Group B Streptococcus Paradigm. Journal of Infectious Diseases. 2009;199(1):108-115. 

Resource types: Peer-reviewed journal

Diseases/vaccines: Group B Streptococcus (GBS)

Topics: Vaccine safety and performance, Disease/vaccine specific information, Vaccine stabilization and formulation

Regions: Global