Presentation Matters: Buffers, Packaging, and Delivery Devices for New, Oral Enteric Vaccines for Infants
This article, published in Human Vaccines & Immunotherapeutics, highlights the importance of final vaccine presentation features in achieving optimal vaccine impact for new oral enteric vaccine candidates. Oral administration of vaccines against bacterial pathogens like enterotoxigenic Escherichia coli and Shigella is simpler and more acceptable than injection via needle and syringe, particularly for infants. However, such vaccine candidates must be buffered against low stomach pH, formulated in minimal dose volumes, and filled into containers that are compatible with vaccine formulations yet have minimal impact on the cold chain. Additionally, the administration device must be accurate, safe, and easy to use by minimally trained health care workers in low-resource settings. The authors recommend that product designers take such features into account early in product development in order to achieve the greatest possible impact for oral enteric vaccines.
Author: Lal M, Jarrahian C
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Citation: Lal M, Jarrahian C. Presentation Matters: Buffers, Packaging, and Delivery Devices for New, Oral Enteric Vaccines for Infants. Human Vaccines & Immunotherapeutics. 2017;13(1):46-49.
Resource types: Peer-reviewed journal
Diseases/vaccines: Shigellosis and enterotoxigenic Escherichia coli (ETEC)