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Safety, Tolerability, and Immunogenicity of Pentavalent Rotavirus Vaccine Manufactured by a Modified Process

This article, published in the Pediatric Infectious Disease Journal, describes the results of a Phase 3 study of a modified formulation of RotaTeq® (RV5) rotavirus vaccine that was developed to be stable at 37°C for 7 days and that has an extended expiration (36 months) when stored at 2°C to 8°C. The trial found that the modified formulation had comparable safety and immunogenicity profiles as the currently licensed RV5 vaccine. A vaccine that is stable at room temperature may be more convenient for vaccinators, particularly in places where the cold chain is unreliable.

Author: Martinón-Torres F, Dionne M, Greenberg D, et al.

Published: 2017

» Visit web page (English)

(Located at www.ncbi.nlm.nih.gov)

Citation: Martinón-Torres F, Dionne M, Greenberg D, et al. Safety, Tolerability, and Immunogenicity of Pentavalent Rotavirus Vaccine Manufactured by a Modified Process. Pediatric Infectious Disease Journal. 2017;Early Online Publication.

Resource types: Peer-reviewed journal

Diseases/vaccines: Rotavirus

Topics: Vaccine safety and performance, Disease/vaccine specific information, Vaccine stabilization and formulation

Regions: Global