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Rotavirus Vaccine Effectiveness in Low-Income Settings: An Evaluation of the Test-Negative Design

This article, published in Vaccine, reports the results of a study evaluating the use of the test-negative design (TND) to estimate rotavirus vaccine effectiveness in low-income settings. The results showed that the TND vaccine effectiveness estimates were nearly equivalent to original randomized placebo-controlled trial vaccine efficacy estimates, supporting the TND as a suitable epidemiologic study design to measure rotavirus vaccine effectiveness in low-income settings.

Author: Schwartz LM, Halloran ME, Rowhani-Rahbar A, Neuzil KM, Victor JC

Published: 2017

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(Located at www.sciencedirect.com)

Citation: Schwartz LM, Halloran ME, Rowhani-Rahbar A, Neuzil KM, Victor JC. Rotavirus Vaccine Effectiveness in Low-Income Settings: An Evaluation of the Test-Negative Design. Vaccine. 2017;35(1):184-190.

Resource types: Peer-reviewed journal

Diseases/vaccines: Rotavirus

Topics: Vaccine safety and performance, Disease/vaccine specific information

Regions: Global