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Impact of Placental Malaria and Hypergammaglobulinemia on Transplacental Transfer of Respiratory Syncytial Virus Antibody in Papua New Guinea

As maternal immunization becomes an increasingly important strategy for protection of very young infants, identification of factors that could impact vaccine effectiveness by modifying the efficiency of transplacental antibody transport will be critical. This article, published in the Journal of Infectious Diseases, reports the results of a study that measured respiratory syncytial virus (RSV) neutralizing antibodies in maternal/cord pairs. The results showed that one-third of infants were born without protective levels of RSV neutralizing antibody, confirming the need to increase levels in pregnant women through maternal immunization. ABSTRACT ONLY. (Learn how users in developing countries can gain free access to journal articles.)

Author: Atwell JE, Thumar B, Robinson LJ, et al.

Published: 2016

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(Located at jid.oxfordjournals.org)

Citation: Atwell JE, Thumar B, Robinson LJ, et al. Impact of Placental Malaria and Hypergammaglobulinemia on Transplacental Transfer of Respiratory Syncytial Virus Antibody in Papua New Guinea. Journal of Infectious Diseases. 2016;213(3):423-431.

Resource types: Peer-reviewed journal

Diseases/vaccines: Malaria, Respiratory syncytial virus (RSV)

Topics: Disease/vaccine specific information

Regions: Oceania