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Use of Quantitative Molecular Diagnostic Methods to Identify Causes of Diarrhoea in Children: A Reanalysis of the GEMS Case-Control Study

This article, published in The Lancet, reports the results of a study that reanalyzed the Global Enteric Multicenter Study data to identify the leading causes of diarrhea in children under five years of age in sub-Saharan Africa and south Asia. The authors found that the six most attributable pathogens, in descending order, were Shigella, rotavirus, adenovirus 40/41, heat stable enterotoxin producing E. coli, Cryptosporidium, and Camplyobacter. These six pathogens accounted for 77.8 percent of all attributable diarrhea, indicating a high burden of disease and for which targeted prevention and treatment interventions should be prioritized.

Author: Liu J, Platts-Mills JA, Juma J, et al.

Published: 2016

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(Located at www.thelancet.com)

Citation: Liu J, Platts-Mills JA, Juma J, et al. Use of Quantitative Molecular Diagnostic Methods to Identify Causes of Diarrhoea in Children: A Reanalysis of the GEMS Case-Control Study. The Lancet. 2016;388(10051):1291-1301.

Resource types: Peer-reviewed journal

Diseases/vaccines: Shigellosis and enterotoxigenic Escherichia coli (ETEC), Rotavirus

Topics: Disease burden and surveillance, Disease/vaccine specific information

Regions: Africa, Asia