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Transmission-Blocking Activity is Determined by Transmission-Reducing Activity and Number of Control Oocysts in Plasmodium falciparum Standard Membrane-Feeding Assay

Malaria transmission-blocking vaccines (TBVs) are potentially helpful tools for malaria eradication. The standard membrane-feeding assay (SMFA) is considered one of the “gold standard” assays for TBV development. However, lack of consensus in reporting results from SMFA has made it very challenging to compare results from different studies. Two main readouts, percent inhibition in mean oocyst count per mosquito and percent inhibition in prevalence of infected mosquitoes, have been used widely. This study, published in Vaccine, explains how oocyst data was statistically modeled in SMFA using data from 105 independent feeding experiments including 9,804 mosquitoes.

Author: Miura K, Swihart BJ, Deng B, et al.

Published: 2016

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(Located at www.sciencedirect.com)

Citation: Miura K, Swihart BJ, Deng B, et al. Transmission-Blocking Activity is Determined by Transmission-Reducing Activity and Number of Control Oocysts in Plasmodium falciparum Standard Membrane-Feeding Assay. Vaccine. 2016;34(35):4145–4151.

Resource types: Peer-reviewed journal

Diseases/vaccines: Malaria

Topics: Disease/vaccine specific information

Regions: Global