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Safety and High Level Efficacy of the Combination Malaria Vaccine Regimen of RTS,S/AS01B With Chimpanzee Adenovirus 63 and Modified Vaccinia Ankara Vectored Vaccines Expressing ME-TRAP

The need for a highly efficacious vaccine against Plasmodium falciparum remains pressing. This article, published in The Journal of Infectious Diseases, reports the results of a study that assessed the safety, efficacy, and immunogenicity of a schedule combining two distinct vaccine types in a staggered immunization regimen: one inducing high-titer antibodies to circumsporozoite protein (RTS,S/AS01B) and the other inducing potent T-cell responses to thrombospondin-related adhesion protein (TRAP) by using a viral vector. The authors found that the regimen was immunogenic and safe. The high level of sterile efficacy observed is encouraging for further evaluation of combination approaches using these vaccine types.

Author: Rampling T, Ewer KJ, Bowyer G, et al.

Published: 2016

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(Located at jid.oxfordjournals.org)

Citation: Rampling T, Ewer KJ, Bowyer G, et al. Safety and High Level Efficacy of the Combination Malaria Vaccine Regimen of RTS,S/AS01B With Chimpanzee Adenovirus 63 and Modified Vaccinia Ankara Vectored Vaccines Expressing ME-TRAP. Journal of Infectious Diseases. 2016;214(5):772-781.

Resource types: Peer-reviewed journal

Diseases/vaccines: Malaria

Topics: Vaccine safety and performance, Disease/vaccine specific information

Regions: Global