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Fractional Third and Fourth Dose of RTS,S/AS01 Malaria Candidate Vaccine: A Phase 2a Controlled Human Malaria Parasite Infection and Immunogenicity Study

This article, published in The Journal of Infectious Diseases, describes how immunization regimens, including a delayed fractional third dose, were assessed for potential increased protection against malaria and immunologic responses. The authors found that a delayed third fractional vaccine dose improved immunogenicity and protection against infection, and optimization of the RTS,S/AS01 immunization regimen may lead to improved approaches against malaria.

Author: Regules JA, Cicatelli SB, Bennett JW, et al.

Published: 2016

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(Located at jid.oxfordjournals.org)

Citation: Regules JA, Cicatelli SB, Bennett JW, et al. Fractional Third and Fourth Dose of RTS,S/AS01 Malaria Candidate Vaccine: A Phase 2a Controlled Human Malaria Parasite Infection and Immunogenicity Study. The Journal of Infectious Diseases. 2016;214(5):762-771.

Resource types: Peer-reviewed journal

Diseases/vaccines: Malaria

Topics: Vaccine safety and performance, Disease/vaccine specific information

Regions: North America and Europe